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目的观察辛伐他汀治疗伴颈动脉粥样硬化的高血脂患者的疗效和安全性,评价其临床应用效果,为今后临床治疗提供参考和借鉴。方法本研究随机选取我院2012年3月~2013年3月期间确诊为伴颈动脉粥样硬化的高血脂患者120例,采用随机数字法将其分为两组,对照组给予饮食控制治疗,观察组给予辛伐他汀20mg/d口服治疗,疗程4个月,对比分析两组在治疗前后IMT、TG、TC、LDL-C、HDL-C的变化情况,评价用药疗效。结果两组患者疗程结束后临床症状和体征有所变化,观察组患者的血脂降低程度较治疗前具有显著性差异(P<0.05),治疗后的IMT也比治疗前有所明显减少(P<0.05);对照组的以上指标却未发生明显变化。结论对伴颈动脉粥样硬化的高血脂患者而言,辛伐他汀能起到良好的降脂作用,而且还能起到稳定甚至减轻患者动脉粥样硬化的作用,疗效显著且安全性高,值得在临床实践中广泛的应用和推广。
Objective To observe the efficacy and safety of simvastatin in the treatment of patients with hyperlipemia with carotid atherosclerosis and to evaluate the clinical effect of simvastatin in clinical treatment and provide references for clinical treatment in the future. Methods A total of 120 patients with hyperlipemia diagnosed as carotid atherosclerosis in our hospital from March 2012 to March 2013 were randomly selected. They were divided into two groups by random number method. The control group was given diet control treatment, The observation group was given simvastatin 20mg / d orally for 4 months. The changes of IMT, TG, TC, LDL-C and HDL-C in both groups before and after treatment were compared to evaluate the curative effect. Results The clinical symptoms and signs of the patients in the two groups changed after treatment. The level of serum lipids in the observation group was significantly lower than that before treatment (P <0.05), and the IMT after treatment was significantly lower than that before treatment (P < 0.05); the above indicators of the control group did not change significantly. Conclusion Simvastatin can play a good lipid-lowering effect on patients with hyperlipemia with carotid atherosclerosis, but also can play a role in stabilizing or even reducing atherosclerosis in patients with significant efficacy and safety, Worth in clinical practice is widely used and promoted.