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巨噬细胞被少量内毒素多次刺激后则能引起内毒素耐受现象 ,主要机制为LPS信号转导功能障碍。全身性炎症反应综合征以及脓毒症患者均具有内毒素耐受的特征 ,可作为其免疫功能失调的重要标志。
Macrophages after being stimulated by a small amount of endotoxin can cause endotoxin tolerance, the main mechanism is LPS signaling dysfunction. Systemic inflammatory response syndrome and endotoxin tolerance in patients with sepsis can be used as an important indicator of immune dysfunction.