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本文报告用MNNG溶液(250ug/ml),拌喂普通食物复制家狗胃癌模型的实验结果。在10只狗中,三只诱发了微小胃癌。共发现16个癌灶。分布在胃体和胃底、大小弯,为多发性;组织类型为高分化管状腺癌(9/16),及印戒细胞癌(7/16),位于粘膜内或粘膜下浸润;肉眼类型属Ⅱ_(b-c)型。系统地观察了各种癌前期病变的病理组织学变化及其与胃癌发生的关系。研究表明:重度慢性萎缩性胃炎伴重度非典型腺体增生是重要的癌前期病变,并提出了狗微小胃癌组织发生模式的初步设想。
This article reports the results of replicating the dog’s stomach cancer model with MNNG solution (250ug/ml) mixed with common food. Of the 10 dogs, three induced minimal gastric cancer. A total of 16 cancer foci were found. Located in the corpus and stomach, large and small, curved, multiple; tissue type is well-differentiated tubular adenocarcinoma (9/16), and signet ring cell carcinoma (7/16), located in the mucosa or submucosal infiltration; the naked eye type Type II_(bc) type. The pathological changes of various precancerous lesions and their relationship with gastric cancer were systematically observed. Studies have shown that: severe chronic atrophic gastritis with severe atypical glandular hyperplasia is an important precancerous lesion, and put forward a preliminary idea of the pattern of dog micro-gastric tissue formation.