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目的:评价特布他林与布地奈德雾化吸入对儿童支气管哮喘患者的疗效及其对血清TNF-α、IL-6水平和肺功能的影响。方法:选取2012年6月—2016年5月间收治的支气管哮喘儿童患者82例,将其分为对照组40例和观察组42例;对照组患者给予吸氧、抗过敏、消炎、止咳等常规治疗,观察组患者则在对照组基础上给予特布他林及布地奈德雾化吸入治疗,7 d为1疗程,比较两组患儿治疗后的总有效率的差异和肺功能、炎症各指标以及喘息、咳嗽、咳痰等症状评分值的改善情况。结果:治疗后,两组患者喘息、咳嗽、咳痰等症状评分值、TNF-α、IL-6、Hs-CRP测得值低于治疗前(P<0.05);观察组患者治疗后用力肺活量(FVC)、第1秒用力呼气量(FEV1)、FEV1/FVC等肺功能指标高于对照组(P<0.05),总有效率为95.24%高于对照组为77.50%(P<0.05)。结论:特布他林与布地奈德联用雾化吸入治疗儿童支气管哮喘的疗效较为显著,可有效地改善肺功能和炎症指标。
Objective: To evaluate the effect of inhalation of terbutaline and budesonide on bronchial asthma in children and its effect on serum TNF-α, IL-6 and pulmonary function. Methods: Totally 82 children with bronchial asthma admitted from June 2012 to May 2016 were divided into control group (n = 40) and observation group (n = 42). Patients in the control group were given oxygen, anti-allergy, anti-inflammatory, The patients in the observation group were treated with inhalation of terbutaline and budesonide on the basis of the control group, 7 days for one course of treatment. The differences of total effective rate and pulmonary function and inflammation between the two groups were compared Indicators and wheezing, cough, sputum and other symptoms score improvement. Results: After treatment, the scores of wheezing, cough and expectoration, TNF-α, IL-6 and Hs-CRP in the two groups were lower than those before treatment (P <0.05); the forced vital capacity (P <0.05). The total effective rate was 95.24%, which was significantly higher than that of the control group (77.50%, P <0.05) . Conclusion: The therapeutic effect of terbutaline and budesonide combined with inhalation on bronchial asthma in children is more significant, which can effectively improve the indexes of lung function and inflammation.