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众所周知,黑人哮喘发生率和死亡率比白人高,这种差别不能仅用收入偏低等有关社会经济因素来解释,还应充分考虑种族与某些药物反应的关系。不同人种不仅在药物代谢动力学方面存在差别,而且在药物效应动力学上。如β受体的数量和功能也有差别。淋巴细胞上β受体数量多少常可作为处于哮喘状态的机体β受体功能状态的一个指标。本研究目的在于验证哮喘患者中黑人淋巴细胞上的β受体数量较白人少的假设。研究对象为16例对乙酰甲胆碱诱发试验为阳性的哮喘患者,年龄18～37岁,其中黑人8例(7男1女),白人8例(4男4女)。
It is well-known that blacks have higher rates of asthma and mortality than whites. This difference can not be explained by socio-economic factors such as low incomes. The relationship between race and certain drugs should also be fully taken into account. Not only do different ethnicities differ in their pharmacokinetics but also in pharmacodynamic effects. Such as the number and function of β receptors are also different. The number of beta receptors on lymphocytes often serves as an indication of the functional status of the beta receptors in the asthmatic state. The aim of this study was to validate the hypothesis that there are fewer beta receptors on black lymphocytes in asthmatics than in whites. The subjects were 16 asthmatics who were positive for methacholine-induced test and were 18 to 37 years old, of whom 8 (7 males and 1 females) were black, 8 were white (4 males and 4 females).