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目的奥卡西平与卡马西平用于原发性三叉神经痛治疗的效果比较。方法选取原发性三叉神经痛患者213例,随机分为奥卡西平组107例和卡马西平组106例。奥卡西平组予奥卡西平治疗,卡马西平组予卡马西平治疗。观察比较2组临床治疗效果和不良反应发生情况。结果奥卡西平组总有效率为96.26%,高于卡马西平组的78.30%(P<0.05);奥卡西平组不良反应发生率为2.79%,低于卡马西平组的20.75%(P<0.05)。结论奥卡西平用于原发性三叉神经痛治疗,临床效果较卡马西平显著,且不良反应更小,值得临床推广应用。
Objective To compare the efficacy of oxcarbazepine and carbamazepine in the treatment of primary trigeminal neuralgia. Methods Totally 213 patients with primary trigeminal neuralgia were randomly divided into oxcarbazepine group (n = 107) and carbamazepine group (n = 106). Oxcarbazepine was given to oxcarbazepine, and carbamazepine was given to carbamazepine. Observation and comparison of two groups of clinical treatment and adverse reactions occurred. Results The total effective rate of oxcarbazepine group was 96.26%, higher than that of 78.30% of carbamazepine group (P <0.05). The incidence of adverse reactions in oxcarbazepine group was 2.79%, which was lower than that of carbamazepine group (P <0.05). Conclusion oxcarbazepine for the treatment of primary trigeminal neuralgia, the clinical effect than carbamazepine significant, and the adverse reactions smaller, worthy of clinical application.