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1979年由中熊等首次报道碘苯酶(Lip)肝动脉注入后能聚集于肝癌灶内。作者对25例肝癌注入碘苯酯进行了研究。其中肝细胞癌20例,胆管细胞癌1例,结肠癌肝转移3例,胃癌肝转移1例。肿瘤直径1～11.5cm。将全部病例分为两组,单纯注入Lip者17例,2例为Lip+Adriamycin30mg混合注入。6例是Lip+Adriamycin30mg注入,再用明胶海绵片进行细栓塞,简称Lip-TAE组。23例于Lip注入后7～80日切除,另2例分别于120日及25日尸检。将肝癌肿瘤染色与Lip动注后5日内的CT图像及组织学图像对比,另外将肿瘤中任意5mm厚切片的低千伏X线影像与同层面组织学图象对比。作者见到,无肿瘤染色者4例,其
In 1979, it was first reported by Zhong Xiong et al. that hepatic arterial injection of Lipase can accumulate in liver cancer. The authors studied the injection of iodophenyl ester into 25 cases of liver cancer. There were 20 cases of hepatocellular carcinoma, 1 case of cholangiocellular carcinoma, 3 cases of colon metastases, and 1 case of liver metastases from gastric cancer. The tumor diameter was 1 to 11.5 cm. All cases were divided into two groups, 17 cases were injected with Lip alone, and 2 cases were mixed with 30 mg of Lip+Adriamycin. Six patients were injected with Lip+Adriamycin30mg and then finely embolized with gelatin sponge tablets, referred to as Lip-TAE group for short. Twenty-three patients were resected 7 to 80 days after Lip injection. The other 2 patients were autopsied on days 120 and 25 respectively. Hepatoma tumor staining was compared with CT images and histological images within 5 days after Lip injection. In addition, any 5-mm thick X-ray image of the tumor was compared with histological histological images. The authors saw 4 patients without tumor staining, and