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结直肠癌伴神经内分泌分化是一种较为常见的现象。较多研究显示结直肠癌中神经内分泌细胞起源于内胚层的多潜能干细胞。结直肠癌的神经内分泌分化与IL-1,IL-6,转化生长因子β(transforming growth factorβ,TGF-β),B细胞淋巴瘤基因2(B-cell lymphoma gene 2,Bcl-2),p53基因,N-myc下游调节基因1(N-myc down-stream regulated gene 1,NDRG1),再生基因4(regenerating geneⅣ,RegⅣ)等有关。多数学者认为神经内分泌分化的出现预示着较差的预后,但近来很多研究显示神经内分泌分化的出现与预后无关。
Colorectal cancer with neuroendocrine differentiation is a more common phenomenon. More studies have shown that endocrine neuroendocrine cells in colorectal cancer stem from pluripotent stem cells. The neuroendocrine differentiation of colorectal cancer is associated with the expression of IL-1, IL-6, transforming growth factor β (TGF-β), B-cell lymphoma gene 2 (Bcl- Gene, N-myc down-stream regulated gene 1 (NDRG1), regenerating gene Ⅳ (RegⅣ) and so on. Most scholars believe that the emergence of neuroendocrine differentiation indicates a poor prognosis, but many recent studies have shown that neuroendocrine differentiation has nothing to do with the prognosis.