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目的综合评价铅中毒对儿童注意力缺陷多动障碍的影响。方法采用meta分析方法,对1992—2012年关于铅中毒与儿童注意力缺陷多动障碍相关的病例对照研究的文献进行分析。结果纳入6篇病例对照研究文献,累计病例数为1 440例,对照组1 388例。结果显示,铅中毒与儿童注意力缺陷多动障碍的发生关联明显(Z=4.52,P<0.05),合并OR值为2.91,OR 95%CI为1.83~4.62。结论铅中毒是儿童注意力缺陷多动障碍的一个危险因素,会增加儿童患注意力缺陷多动障碍的概率。
Objective To evaluate the impact of lead poisoning on children with attention deficit hyperactivity disorder. Methods Meta-analysis was used to analyze the literature from 1992 to 2012 on case-control studies of lead poisoning and attention deficit hyperactivity disorder in children. Results Six case-control studies were included, with a total of 1 440 cases and 1 388 cases in the control group. The results showed that the association between lead poisoning and ADHD in children was significant (Z = 4.52, P <0.05). The combined OR was 2.91 and the OR 95% CI was 1.83-4.62. Conclusion Lead poisoning is a risk factor for attention deficit hyperactivity disorder in children and increases the probability of children with attention deficit hyperactivity disorder.