多年来,左旋甲状腺素常用来治疗缺碘性甲状腺肿,这种治疗方法的理由是它可抑制垂体的 TSH 的分泌,而 TSH 被认为是刺激甲状腺生长的主要物质。然而,过去几年间,许多体内、外的研究已进一步丰富了有关甲状腺生长的病理生理学的概念,并且提供了甲状腺内部的碘含量减少明显是导致细胞生长延缓的最重要的致病因素。而 TSH 刺激细胞本身肥大,但不影响细胞的数目。基于这些资料,人们认为在理论上应用 For many years, L-thyroxine was commonly used to treat iodine deficiency goiter. The reason for this treatment is that it suppresses the secretion of TSH in the pituitary gland. TSH is thought to be the main substance that stimulates thyroid gland growth. However, in the past few years, many in vitro and in vivo studies have further enriched the concept of pathophysiology of thyroid gland growth and provided that the reduction of iodine content within the thyroid is clearly the most important causative agent of delayed cell growth. TSH stimulates the cells themselves to hypertrophy, but does not affect the number of cells. Based on these data, people think that in theory