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《中国药典》2005年版二部“盐酸小檗碱片”含量测定项下,规定沸水溶解用滤膜(0.45μm)过滤。因为盐酸小檗碱在冷水中溶解度比游离碱小(盐酸盐为1:500),但易溶于热水中。但有些基层单位和生产企业用滤纸过滤可能出现含量测定结果偏低。笔者对3个厂家5个批号的产品采用滤
“Chinese Pharmacopoeia” 2005 edition two “berberine tablets ” content determination, the provisions of boiling water filtration (0.45μm) filter. Because berberine hydrochloride is less soluble in cold water than free base (1: 500 hydrochloride), it is readily soluble in hot water. However, some grass-roots units and manufacturing enterprises with filter paper may appear low level of content determination. The author of the three manufacturers five batches of products using filter