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利用烧伤动物模型,探讨了特异性抗菌免疫核糖核酸(i-RNA)预防烫伤大鼠大肠杆菌感染的作用及机理。结果发现,治疗组经特异性抗菌i-RNA治疗后所测三项指标(痂下组织细菌定量、心血细菌培养及伤后10天内存活率)均明显优于对照组;并发现治疗组腹腔巨噬细胞(Mφ)吞噬功能、脾淋巴细胞转化率及IL-2渗生能力也显著高于对照组。提示特异性抗菌i-RNA对烧伤动物感染有一定的预防作用,可增强烧伤动物的免疫功能,促进其伤后受抑制的免疫功能尽早得以恢复。
Using burn animal model, the effect and mechanism of specific anti-bacterial immunological ribonucleic acid (i-RNA) on prevention of colibacillosis in scalded rats were discussed. The results showed that three indicators (scab tissue bacterial count, blood bacterial culture and survival rate within 10 days after injury) in the treatment group were significantly better than those in the control group after the specific antimicrobial i-RNA treatment. The results showed that the abdominal cavity giant Phagocytic function of Mφ, splenic lymphocyte transformation rate and IL-2 infiltration capacity were also significantly higher than those of the control group. It is suggested that specific antimicrobial i-RNA can prevent the infection of burn animals to a certain extent, enhance the immune function of burned animals and promote the recovery of the suppressed immune function as early as possible.