【摘 要】
：
Main observation and conclusionrnThe new racemic and dimeric indole alkaloids with the characteristic cyclopenta[b]indole backbone,(+)-and (-)-spondomine (1a/1b),were isolated from a cultured sponge Tedania anhelans.A semi-synthesis was employed to obtain
【机 构】
：
Key Laboratory of Marine Drugs,Chinese Ministry of Education,School of Medicine and Pharmacy Departm
论文部分内容阅读
Main observation and conclusionrnThe new racemic and dimeric indole alkaloids with the characteristic cyclopenta[b]indole backbone,(+)-and (-)-spondomine (1a/1b),were isolated from a cultured sponge Tedania anhelans.A semi-synthesis was employed to obtain 1a/1b and the other four stereoi-somers 1c-1f.Their structures were determined by spectroscopic analysis,single-crystal X-ray,and quantum chemical calculations.Six stereoisomers differ in bioactivity according to their absolute configurations.Especially,(+)-spondomine (1a) displayed cytotoxicity against the K562 cell line and exhibited stronger Wnt and HIF1 dual signaling inhibitory activity at 5 μmol/L than the positive control,which offers an exciting starting point for further investigations.All stereoisomers significantly promoted angiogenesis and showed moderate anti-inflammation in zebrafish.A quantum chemical calculation and deuteration experiment were applied to unveil the re-action mechanism which guides the synthesis of the target compounds.
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