在欧美国家,乳腺癌在女性恶性肿瘤发病率中居首位,死亡率居第二位。而在我国,尤其是北京、上海等地区的乳腺癌发病率已经逐渐接近西方乳腺癌高发国家[1]。乳腺癌改良根治术作为临床较为常见的Ⅰ级手术,其术后切口预防感染对于保证手术治疗效果有重要意义。我国卫生部《抗菌药物临床应用指导原则》中对Ⅰ级类手术围手术期是否使用抗生素有明确规定[2]。为探讨乳腺癌患者在行改良根治术后切口感染与围手术期抗生素的相关性,我们选取最近几年 In Europe and the United States, breast cancer ranks first in the incidence of female malignant tumors, with the second highest mortality rate. In China, especially in Beijing, Shanghai and other regions of the incidence of breast cancer has gradually approached the high incidence of breast cancer in Western countries [1]. Modified radical mastectomy as a clinical grade Ⅰ surgery is more common, and its postoperative wound infection prevention is of great significance to ensure the efficacy of surgical treatment. China’s Ministry of Health “antibacterial clinical guidelines” in the class Ⅰ perioperative surgical use of antibiotics have a clear prescription [2]. To explore the breast cancer patients underwent modified radical mastectomy wound infection and perioperative antibiotics, we select the most recent years