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目的：探讨复合辅酶对急性酒精中毒所致心肌损伤的保护作用。方法选取近三年急诊收治的急性酒精中毒患者中有心肌损伤者204例，随机分为对照组和研究组各102例。分别给予常规治疗和加用复合辅酶治疗，比较两组治疗前后心电图、心肌酶谱的变化。结果各指标治疗前组间比较均无明显差异，治疗后组间比较：AST无显著差异，研究组心电图、LDH、CK、CK-MB均显著降低；各指标治疗前后组内比较均有显著改善。结论复合辅酶可有效改善急性酒精中毒患者的心肌损伤。“,”Objective To discuss the role of protection of compound coenzyme on myocardial injury caused by acute alcohol poisoning.Methods 204 cases of patients with myocardial injury caused by acute alcohol poisoning,who were admitted and treated in our hospital in nearly three years,were selected and randomly divided into control group and research group,with 102 cases in each group.Two groups were performed with conventional treatment and compound coenzyme treatment respectively and the changes of electrocardiogram and myocardial enzyme spectrum of two groups before and after treatment were compared.Results Through the comparison within the group before the treatment,all the indicators have no obvious difference;through comparison within the group after the treatment:there is no signiifcant difference of AST,and the electrocardiogram,LDH,CK,CK-MB of research group were signiifcantly decreased;through comparison within the group before and after treatment,all the indicators have signiifcant improvement.Conclusion Compound coenzyme can effectively improve the patients’ acute alcoholism caused by acute alcohol poisoning.