目的　探讨帕金森病 (PD)特征性震颤与内苍白球 (GPi)神经元电活动的关系 ,指导手术靶点的精确定位。方法　 10例PD患者接受了立体定向苍白球腹后部毁损术 ,术中应用微电极和肌电 (EMG)记录技术 ,采集GPi神经元和肢体震颤的生物电活动。术后应用分析软件甄别单细胞及其电活动特点 ,分析其与震颤症状的关系 ,并进行相关性检验。结果　在GPi共记录到了 112个神经元 ,有 5 7个 (5 1% )震颤细胞 ,且主要分布在视束上方 4～ 6mm ,其簇状放电的节律与肢体震颤的节律高度一致 (4～ 6Hz) ,R2 =0 71(P <0 0 1)。毁损震颤细胞导致震颤症状的消失。结论　震颤型PD患者的GPi存在电活动与肢体震颤节律一致的震颤细胞。该细胞的发现和定位 ,对于指导手术毁损的部位和范围具有重要意义。 Objective To explore the relationship between the characteristic tremor of Parkinson’s disease (PD) and the electrical activity of the inner globus pallidus (GPi) neurons and to guide the precise location of the surgical targets. Methods Ten patients with PD underwent stereotactic paleotidotomy. Electroencephalogram (GPI) neurons and limb tremor were collected during the operation using microelectrode and electromyography (EMG) recording technique. Postoperative application of software to screen single cell and its characteristics of electrical activity, analysis of its relationship with tremor symptoms, and correlation test. Results A total of 112 neurons were recorded in the GPi, 57 (51%) of which were tremor cells and mainly distributed 4 ~ 6mm above the optic tract. The rhythmicity of the cluster discharge was highly consistent with the limb tremor (4 ~ 6 Hz), R2 = 0 71 (P <0 0 1). Depleting chattering cells leads to the disappearance of tremor symptoms. Conclusions Tremor-type PD patients have tremor cells whose electrical activity is consistent with limb tremor rhythm. The discovery and localization of this cell is of great importance for guiding the site and extent of surgical damage.