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目的：研究胃肠舒对肠道平滑肌的作用。方法：用小鼠在体实验和家兔离体肠管研究胃肠舒对肠道平滑肌的作用，均以吗丁啉为阳性对照。结果：胃肠舒３００ｍｇ·ｋｇ－１、吗丁啉１．５ｍｇ·ｋｇ－１灌胃，均能提高小鼠卡红肠道推进率，分别为７６．０２％、７４．４２％（Ｐ＜０．０１）。在家兔离体肠管上，胃肠舒４２０ｍｇ·Ｌ－１、吗丁啉１．６７ｍｇ·Ｌ－１均能使离体肠道平滑肌自发活动收缩幅度加大（Ｐ＜０．０１），但收缩频率无明显改变（Ｐ＞０．０５）。结论：胃肠舒能兴奋胃肠道平滑肌，加快肠蠕动
Objective: To study the effect of gastrointestinal comfort on intestinal smooth muscle. Methods: The effect of GZX on intestine smooth muscle was studied in vivo and in vitro in rabbits with domperidone as positive control. Results: Gastrointestinal Shu 300mg · kg-1, morphine 1.5mg · kg-1 gavage, can improve the card red intestinal propulsion rate were 76.02%, 74.42% (P < 0.01). In the isolated rabbit intestine, gastrointestinal Shou 420mg · L-1, morphine 1.67mg · L-1 can make isolated intestinal smooth muscle spontaneous activity contraction amplitude increased (P <0.01), but No significant change in the frequency of contraction (P> 0.05). Conclusion: Gastrointestinal Shu can stimulate gastrointestinal smooth muscle, accelerate intestinal peristalsis