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目的:探讨高容量血液滤过(HVHF)在重症腹腔感染术后MODS患者治疗中的临床效果。方法:腹腔重症感染术后进行HVHF治疗的MODS患者(17例),观察治疗前后患者炎性介质(TNF-a、IL-6、IL-8)、氧合指数、APACHE-Ⅱ评分。结果:17例患者经HVHF首次治疗后APACHE-Ⅱ和TNF-a、IL-6、IL-8也有明显下降,氧合指数改善,差异均有统计学意义(P<0.05)。经多次治疗后,最终患者APACHE-Ⅱ评分明显下降(P<0.05)。结论:HVHF可以改善严重脓毒血症患者的呼吸功能及生命体征,并能缓解病情。
Objective: To investigate the clinical effect of high volume hemofiltration (HVHF) in the treatment of MODS patients after severe abdominal infection. Methods: MODS patients (17 cases) treated with HVHF after severe intraperitoneal infection were divided into two groups. The levels of inflammatory mediators (TNF-a, IL-6 and IL-8), oxygenation index and APACHE-Ⅱ were observed before and after treatment. Results: The APACHE-Ⅱ, TNF-a, IL-6 and IL-8 in 17 patients after HVHF treatment were significantly lower than those in the control group (P <0.05). After multiple treatments, APACHE-Ⅱ scores decreased significantly in the final patients (P <0.05). Conclusion: HVHF can improve respiratory function and vital signs in patients with severe sepsis and relieve the disease.