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对74例正常婴幼儿和70例患下呼吸道感染的婴幼儿同时测定下呼吸道分泌物(LRS)及唾液中SIgA的含量。两组检测对象在性别和年龄分组上无明显差异。结果表明:1LRS和唾液的SIgA含量都与年龄呈正性相关,各年龄组之间SIgA含量也存在着显著性差异(P<0.01);②感染婴幼儿组及其各年龄组的SIgA含量均明显高于正常婴幼儿组及其各年龄组(P<0.01);③LRS的SIgA含量与唾液SIgA含量之间存在密切的相关性(P<0.01)。作者认为婴幼儿下呼吸道感染后局部SIgA增高是一种正常的免疫应答反应,有助于控制感染;SIgA的变化规律可作为鉴别免疫缺陷的指标;应用测定唾液中SIgA间接反映LRS中SIgA水平的方法将推进临床免疫研究开展。
The contents of SIgA in lower respiratory tract secretions (LRS) and saliva were measured simultaneously in 74 normal infants and 70 infants with lower respiratory tract infections. There was no significant difference between the two groups in gender and age grouping. The results showed that the content of SIgA in 1LRS and saliva was positively correlated with age, and the content of SIgA in all age groups was also significantly different (P <0.01). ② The content of SIgA in infants and their infants was significantly higher (P <0.01). (3) There was a close correlation between SIgA content and salivary SIgA content in LRS (P <0.01). The authors believe that elevated SIgA in infants with lower respiratory tract infection is a normal immune response and contributes to the control of infection. The change of SIgA may be used as an index to identify immunodeficiency. The application of SIgA in saliva indirectly reflects the level of SIgA in LRS Methods will promote clinical immunization research.