阿斯匹林哮喘具有症状难以控制和依赖糖皮质激素治疗等特点,且是导致哮喘严重发作的主要因素之一。在花生四烯酸代谢途径中环氧化酶路径的受阻、白三烯生成过多,多种炎症介质的介入,前列腺素E_2的抑制和二十烷代谢的转换,以及未知抗原的免疫识别和病毒感染等均为导致AIA发作的因素。认识AIA的发病机制有利于临床上采取有效治疗。 Aspirin asthma has symptoms that are difficult to control and dependent on glucocorticoid therapy, and is one of the major causes of severe asthma attacks. Blockade of cyclooxygenase pathway, excessive production of leukotrienes, intervention of various inflammatory mediators, inhibition of prostaglandin E 2 and conversion of eicosane metabolism, immunological recognition of unknown antigens and viral infection in the arachidonic acid metabolic pathway And so are the factors that lead to the onset of AIA. Understanding the pathogenesis of AIA is conducive to effective clinical treatment.