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健康志愿者5人,随机、交叉、单剂口服国产和进口格列甲嗪(Glipizide)片5mg,用HPLC法测定口服药前、后不同时间格列甲嗪血药浓度,用RIA法测定C肽血浓度,不同时间的格列甲嗪血药浓度用PKBP-N_1程序计算药动学参数,国产和进口产品的主要药动学参数Tp、Cmax、T_(1/2),AUC均无显著性差异(P>0.05).C肽血浓度与格列甲嗪血浓度呈良好的相关性,服药后第14小时,C肽血浓度显著高于给药前(P<0.05),说明药效持久,提示C肽血药浓度可间接反映格列甲嗪的降血糖药效作用.
Five healthy volunteers were randomized, crossover and single oral administration of domestic and imported glipizide tablets (5mg). The plasma concentrations of glipizide were determined by HPLC before and after oral administration. The plasma concentrations of glipizide were determined by RIA The pharmacokinetic parameters were calculated by PKBP-N_1 program. The main pharmacokinetic parameters Tp, Cmax, T 1/2, AUC of domestic and imported products were not significantly (P> 0.05) .C peptide blood concentration and glimepiride blood concentration showed a good correlation between the 14th hour after taking the C peptide blood concentration was significantly higher than before administration (P <0.05), indicating that the efficacy Long-lasting, suggesting that C-peptide plasma concentration can indirectly reflect the anti-hypoglycemic effect of glipizide.