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目的:观察健脾祛湿方治疗脾虚湿盛型多囊卵巢综合征(PCOS)的临床疗效。方法:选取在本院接受治疗的124例脾虚湿盛型PCOS患者,随机分为治疗组和对照组,每组62例。治疗组采用健脾祛湿方合决雌醇环丙孕酮片治疗,对照组单纯使用决雌醇环丙孕酮片。治疗后评估临床疗效,观察2组治疗前后体质量、体质量指数(BMI)及血清性激素指标的变化。结果:对照组总有效率59.7%,低于治疗组的83.9%(P<0.05)。经治疗后,治疗组的体质量及BMI均较治疗前降低,差异均有统计学意义(P<0.05);对照组的体质量及BMI与治疗前比较,差异均无统计学意义(P>0.05)。经治疗后,治疗组的血清促黄体生成素(LH)、睾酮(T)水平及LH/促卵泡生成素(FSH)比值均较治疗前降低(P<0.05),对照组血清LH及T水平均较治疗前降低(P<0.05)。2组治疗后的FSH、LH、T水平及LH/FSH比值与治疗前比较,差异均无统计学意义(P>0.05)。2组治疗期间均未发生不良反应。结论:健脾祛湿方联合决雌醇环丙孕酮片治疗脾虚湿盛型PCOS,可有效改善患者的BMI及血清性激素指标,效果优于单纯使用决雌醇环丙孕酮片。
Objective: To observe the clinical efficacy of Jianpi Qushi Formula in treating splenomegaly wet polycystic ovary syndrome (PCOS). Methods: A total of 124 patients with splenomegaly and wet-type PCOS who were treated in our hospital were randomly divided into treatment group and control group, with 62 patients in each group. The treatment group with Jianpi Qushi Decoction estradiol cyproterone tablets treatment, the control group of pure use of progesterone cyproterone tablets. After treatment, the clinical efficacy was evaluated. The changes of body mass index, body mass index (BMI) and serum hormone levels before and after treatment were observed. Results: The total effective rate was 59.7% in the control group, which was lower than 83.9% in the treatment group (P <0.05). After treatment, the body weight and BMI of the treatment group decreased compared with those before treatment, the differences were statistically significant (P <0.05); the body weight and BMI of the control group were not significantly different from those before treatment (P> 0.05). After treatment, the serum levels of LH, T and LH / FSH in the treatment group were lower than those before treatment (P <0.05), and the level of serum LH and T in the control group All lower than before treatment (P <0.05). The FSH, LH, T levels and the ratio of LH / FSH after treatment in both groups were not significantly different from those before treatment (P> 0.05). No adverse reactions occurred in the two groups during the treatment. Conclusion: Jianpi Qushi Decoction combined with progesterone and progesterone progesterone tablets in the treatment of spleen dampness-type PCOS, can effectively improve the patient’s BMI and serum sex hormones, the effect is better than the simple use of progesterone progesterone progesterone tablets.