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目的探讨两种不同根除幽门螺旋杆菌方案治疗消化性溃疡成本效果差异。方法选择我院2008年3月至2010年3月幽门螺旋杆菌阳性消化性溃疡患者82例,将以上患者随机分为观察组和对照组。对照组患者给予采用以下三联疗法:奥美拉唑片每天40mg、阿莫西林胶囊每天2g、克拉霉素胶囊每天0.5g口服,疗程为7d。观察组患者采用以下三联疗法:奥美拉唑每天40mg、阿莫西林每天2g,呋喃唑酮每天0.2g口服,疗程为14d。患者成本为药品费用和相关检查费用,其他间接或者隐性成本不计。结果两组患者总有效率比较,差异无统计学意义(P>0.05);观察组患者成本为552元,对照组为613元;两组获得相同疗效,观察组所需成本显著小于对照组。结论奥美拉唑、阿莫西林、呋喃唑酮方案治疗幽门螺旋杆菌感染消化性溃疡成本效果显著优于奥美拉唑、阿莫西林、克拉霉素方案,值得临床借鉴。
Objective To investigate the difference in the cost of peptic ulcer between two different eradication programs of Helicobacter pylori. Methods 82 cases of Helicobacter pylori positive peptic ulcer were selected from March 2008 to March 2010 in our hospital. The above patients were randomly divided into observation group and control group. Patients in the control group were treated with the following triple therapy: Omeprazole tablets 40mg daily, amoxicillin capsules 2g daily, clarithromycin capsules 0.5g orally daily for 7 days. Patients in the observation group were treated with the following triple therapy: omeprazole 40 mg daily, amoxicillin 2 g daily, and furazolidone 0.2 g daily for 14 days. Patient costs for drug costs and related inspection costs, other indirect or hidden costs do not count. Results There was no significant difference in the total effective rate between the two groups (P> 0.05). The cost of the observation group was 552 yuan and the control group was 613 yuan. The two groups had the same curative effect. The cost of the observation group was significantly lower than that of the control group. Conclusion The omeprazole, amoxicillin and furazolidone regimens are superior to omeprazole, amoxicillin and clarithromycin in the treatment of peptic ulcer patients with H. pylori infection, which is worthy of clinical reference.