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多肽类药物如胰岛素,因在胃肠道被分解而不能经口给药,许多病人也不愿意或不能接受一天多次注射给药,况且皮下注射胰岛素吸收的个体差异很大。因此,在非肠道给药途径方面做了许多尝试,如直肠、阴道、鼻腔和气管等途径。由于种种原因,这些尝试没有得到预期结果。本文介绍一种新的尝试,眼滴胰岛素。实验用2～3kg新西兰白兔,戊巴比妥钠30mg/kg麻醉后(iv),股动脉插管,在不同时间采血样品,取样后用肝素化生理盐水补充血容量。四氧嘧啶糖尿病兔(iv,四氧嘧啶
Peptides, such as insulin, can not be administered orally because of breakdown in the gastrointestinal tract. Many patients are unwilling or unable to receive multiple injections a day, and subcutaneous insulin injections vary greatly among individuals. Therefore, many attempts have been made in the area of parenteral administration such as rectal, vaginal, nasal and tracheal. Due to various reasons, these attempts did not achieve the expected results. This article describes a new attempt to drip insulin. Experiments with 2 ~ 3kg New Zealand white rabbits, 30mg / kg sodium pentobarbital anesthesia (iv), femoral artery catheterization, blood samples at different times, after sampling the blood volume with heparinized saline. Alloxan diabetic rabbit (iv, alloxan