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为探索预防卡那霉素耳中毒的途经，以耳廓反射阀（ＰＲ），耳蜗电位（ＣＭ），听神经动作电位（ＮＩ）和耳蜗铺片为观察指标，本实验观察了茯苓对豚鼠卡那霉素耳中毒的影响。实验结果显示，对照组２ＫＨＺＰＲ阀升高２３．４±３．５ｄＢ，而灌服茯苓煎组２ＫＨＺＰＲ阈仅上升１６．２±３．１ｄＢ（Ｐ＜０．０５）。对照组８０ｄＢ短声诱发的微音器电位和听神经动作电位为３３６．２±３５．１ｕＶ和４５４．２±３５．６ｕＶ，而灌服茯苓组为４６４．２±３５．５ｕＶ和５７５．４±４６．３ｕＶ（Ｐ＜０．０５）。耳蜗铺片显示单用卡那霉素动物外毛细胞损害较严重，耳蜗底回外毛细胞缺失率为５７．５％，而服用茯苓组动物耳蜗底回外毛细胞缺失率为３９．６％（Ｐ＜０．０５）。实验结果说明茯苓可减轻卡那霉素中毒性耳损害。
In order to explore the route of prevention of ototoxicity of kanamycin, the effects of auricle reflex valve (PR), cochlear potential (CM), auditory nerve action potentials (NI) and cochlear implants were observed. Mycotoxin poisoning. The experimental results showed that the 2KHZPR valve in control group increased by 23.4 ± 3.5dB, while the 2KHZPR threshold increased only by 16.2 ± 3.1dB (P <0.05). The control group 80dB short-tone induced microphones potential and auditory nerve action potentials of 336.2 ± 35.1uV and 454.2 ± 35.6uV, while the oral administration of Poria group was 464.2 ± 35.5uV and 575.4 ± 46.3uV (P <0.05). Cochlear patch showed that kainamycin alone was more damaged by outer hair cells. The rate of outer hair cell loss at the bottom of cochlear was 57.5%, while the rate of deletion of outer hair cells at the bottom of cochlea was 39.6% (P <0.05). Experimental results show that Poria can reduce kanamycin poisoning ear damage.