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为探索氩激光虹膜切除术后暂时性眼压升高的发生机理，我们观察了３２只家兔氩激光虹膜切除术后１５分钟、６０分钟、６小时、２４小时、４８小时的眼压变化情况和房水内前列腺素Ｅ＿２（ＰＧＥ＿２）浓度的变化与眼压升高的关系以及术前局部应用消炎痛、可的松等药物对术后暂时性眼压升高的防治作用。结果表明：激光术后暂时性眼压升高均发生在术后６小时以内，术后１５分钟就开始升高，６０分钟达高峰，与对照组比较有明显差异（Ｐ＜０．０５），术后暂时性眼压升高的同时均伴有房水内ＰＧＥ＿２浓度的显著升高（Ｐ＜０．０１），术前局部滴用消炎痛和可的松眼药水，术后未发现明显的眼压升高。
To investigate the mechanism of temporary elevated intraocular pressure after argon laser iridotomy, we observed changes of intraocular pressure at 15 minutes, 60 minutes, 6 hours, 24 hours and 48 hours after argon laser iridotomy in 32 rabbits And aqueous humor prostaglandin E2 (PGE2) concentration changes and the relationship between elevated intraocular pressure and preoperative local application of indomethacin, cortisone and other drugs on postoperative temporary intraocular pressure to prevent and control. The results showed that the transient intraocular pressure (IOP) rise after laser operation occurred within 6 hours after operation, and began to increase 15 minutes after operation and reached the peak at 60 minutes, which was significantly different from the control group (P <0.05) Postoperative temporary intraocular pressure was accompanied by a significant increase in aqueous humor PGE 2 concentration (P <0.01), preoperative local drip with indomethacin and cortisone eye drops, no significant postoperative IOP increased.