论文部分内容阅读
为探讨肝癌癌旁组织ＤＮＡ倍体、Ｓ期细胞比率（ＳＰＦ）、甲胎蛋白（ＡＦＰ）和病理分级等指标与患者肿瘤恶性度及预后的关系。对４２例肝癌患者癌旁组织倍体和ＳＰＦ、血清ＡＦＰ及肿瘤病理分级进行同步检测。结果显示患者癌旁组织异倍体检出率为５９．５％。癌旁组织倍体、ＳＰＦ、ＡＦＰ和病理分级之间均密切相关。根据患者对４项指标反应的不同分为预后不同的５级。这样，从Ⅰ级至Ⅴ级患者肿瘤恶性度越来越高，预后越来越差。其５ａ生存率和生存期分别为１００％、８５．７％、５５．６％、４４．４％、０和７５．９个月、６５．１个月、４７．４个月、４４．２个月、８７个月。认为肝癌癌旁组织ＤＮＡ倍体、ＳＰＦ、ＡＦＰ和病理分级等指标综合判断肿瘤恶性度和预后在临床上有重要意义
To explore the relationship between the DNA ploidy, S phase cell ratio (SPF), AFP and pathological grading of hepatocellular carcinoma adjacent tissues to the malignancy and prognosis of patients. The ploidy, SPF, serum AFP and pathological grades of tumor tissues were detected simultaneously in 42 patients with hepatocellular carcinoma. The results showed that the detection rate of paraneoplastic tissue in the patient was 59.5%. Peripheral tissue ploidy, SPF, AFP and pathological grading were closely related. According to the patient’s response to the four indicators, they are divided into five grades with different prognosis. In this way, the degree of malignancy of patients from grade I to grade V is getting higher and higher, and the prognosis is getting worse. The 5-year survival rate and survival time were 100%, 85.7%, 55.6%, 44.4%, 0 and 75.9 months, 65.1 months, 47.4 months, 44.2 respectively. Month, 87 months. It is considered that the comprehensive determination of the degree of malignancy and prognosis of tumors by DNA ploidy, SPF, AFP and pathological grade of liver cancer adjacent tissues is of clinical significance.