Background: Classic Kaposi sarcoma (KS) occurs predominantly among the elderly, with predominance among Jews, Italians, and Greeks. Classic KS has been seen relatively frequently in Peru. Objective: Our purpose was to outline the epidemiological and clinical profile of classic KS in Peru. Methods: Epidemiological and clinical features of all classic KS cases diagnosed between 1969 and 2003 at Hospital Nacional Cayetano Heredia (HNCH) and between 1946 and 2004 at Instituto Nacional de Enfermedades Neoplasicas (INEN) were reviewed and studied retrospectively. Results: An overall incidence of 2.54 per 10,000 attended patients was obtained at the INEN during the 48- year period (mean, 2.39; standard deviation: 1.99; 95% confidence interval, 2.92- 1.86). Twenty- one cases were discovered at HNCH and 106 cases at INEN. A male/female ratio of 2.62:1 was found. Mean age at diagnosis was 68.5 years. Lower limbs were involved in 109 patients (85.8% ); the trunk was involved in 11 patients (8.6% ). Nodules were the most common type of lesion (85.8% ); less commonly found were plaques (27.5% ), macules (12.5% ), papules (12.5% ), and ulcers (8.6% ). Sixty- two patients had no symptoms (48.8% ). Pain was the most common symptom (26.7% ), followed by edema (21.2% ), bleeding (14.9% ), and pruritus (3.9% ). A second primary malignancy was found in 11 patients (8.6% ). Limitations: These results were obtained from patients with classic KS in Peru and may not be applicable to other populations. Conclusion: Classic KS is quite common in Peru with sporadic cases found throughout the country and some clustering in the coastal region. Classic KS in Peru has a clinical presentation that is very similar, but not identical, to the classic KS described in the Mediterranean region, exhibiting some special clinical and epidemiological characteristics with a nodular, nonsymmetric presentation that usually affects the lower extremities. Objective: Our purpose was to outline the epidemiological and clinical profile of classic KS in. Background: Classic Kaposi sarcoma (KS) occurs predominantly among the elderly, with predominance among Jews, Italians, and Greeks. Peru. Methods: Epidemiological and clinical features of all classic KS cases diagnosed between 1969 and 2003 at Hospital Nacional Cayetano Heredia (HNCH) and between 1946 and 2004 at Instituto Nacional de Enfermedades Neoplasicas (INEN) were reviewed and retrospectively. Results: An overall incidence of 2.54 per 10,000 attended patients was obtained at the INEN during the 48-year period (mean, 2.39; standard deviation: 1.99; 95% confidence interval, 2.92-1.86). Twenty- one cases were discovered at HNCH and 106 cases at Mean age at diagnosis was 68.5 years. Lower limbs were involved in 109 patients (85.8%); the trunk was involved in 11 patients (8.6% Sixty-two patients had no (25.8%); less commonly found were plaques (27.5%), macules (12.5%), papules Pain was the most common symptom (26.7%) followed by edema (21.2%), bleeding (14.9%), and pruritus (3.9%). A second primary malignancy was found in 11 patients (8.6% Limitations: These results were obtained from patients with classic KS in Peru and may not be applicable to other populations. Classic KS is quite common in Peru with sporadic cases found throughout the country and some clustering in the coastal region. Classic KS in Peru has a clinical presentation that is very similar, but not identical, to the classic KS described in the Mediterranean region, exhibiting some special clinical and epidemiological characteristics with a nodular, nonsymmetric presentation that normally affects the lower extremities.