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给SD大鼠皮下埋植17-β-雌二醇,60天后,其垂体重量显著增加;垂体前叶细胞明显增生,分化受抑制;用放射免疫法测定血浆催乳素含量显著增加;斑点杂交显示垂体细胞原癌基因c-myc的转录水平也显著增加。
17-β-estradiol was subcutaneously implanted into SD rats, and the pituitary weight increased significantly after 60 days. The anterior pituitary cells were significantly proliferated and the differentiation was inhibited. The content of prolactin in plasma was significantly increased by radioimmunoassay. P-myc transcription of the pituitary cell proto-oncogene also increased significantly.