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目的探讨格拉司琼预防分化型甲状腺癌(DTC)患者~(131)I“清甲”术后呕吐的疗效。方法将行甲状腺全/近全切除术后经病理确诊为甲状腺乳头状癌患者285例,随机分为对照组142例、治疗组143例,对照组采用口服多潘立酮,治疗组采用口含盐酸格拉司琼口腔崩解片以预防呕吐发生。结果治疗组患者呕吐发生率(2.1%),低于对照组患者(9.2%),两组比较,差异有统计学意义(x~2=5.781,P<0.05)。结论口含盐酸格拉司琼口腔崩解片有较好的预防DTC患者~(131)I“清甲”治疗术后呕吐的作用。
Objective To investigate the efficacy of granisetron in the prevention of postoperative vomiting in patients with differentiated thyroid cancer (DTC). Methods A total of 285 patients with pathologically confirmed papillary thyroid carcinoma after thyroidectomy were randomly divided into control group (n = 142), treatment group (n = 143) and oral domperidone control group (n = Joan orally disintegrating tablets to prevent vomiting. Results The incidence of vomiting was 2.1% in the treatment group, which was lower than that in the control group (9.2%). There was significant difference between the two groups (x ~ 2 = 5.781, P <0.05). Conclusion oral granisetron hydrochloride orally disintegrating tablets better prevention of DTC patients with 131I “A” treatment of postoperative vomiting.