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采用核孔滤膜法对ＣＯＰＤ患者稳定期、急性加重期及ＢｉｐＡｐ通气治疗前后的红细胞变形能力（ＲＣＤ）进行了测定。结果发现ＣＯＰＤ急性加重期红细胞滤过指数（ＩＦ）较稳定期明显增高（Ｐ＜０．０５），ＩＦ变化与ＰａＯ２呈高度负相关（ｒ＝－０．７３４），与ＰａＣＯ２呈中度正相关（ｒ＝０．４８９），表明缺氧与红细胞变形能力的下降有非常密切的关系，与二氧化碳的潴留亦有一定的内在联系，给急性加重期病人采用ＢｉｐＡｐ鼻罩式机械通气，改善缺氧和二氧化碳潴留，同时测定红细胞变形能力，表明ＩＦ较通气治疗前下降，统计学分析有显著性差异（Ｐ＜０．０５），说明红细胞变形能力的变化对ＣＯＰＤ病情发展具有一定的影响
The nuclear membrane filtration method was used to determine the erythrocyte deformability (RCD) before and after COPD treatment in stable, acute exacerbation and BipAp ventilation. The results showed that the level of erythrocyte filtration index (IF) in COPD was significantly higher than that in stable phase (P <0.05), and the change of IF was highly negatively correlated with PaO2 (r = -0.734), with a moderate positive correlation with PaCO2 (R = 0.489), indicating that hypoxia has a very close relationship with the decline of erythrocyte deformability, and carbon dioxide retention is also some intrinsic link to the acute exacerbation of patients with BipAp nasal mask mechanical ventilation to improve hypoxia And carbon dioxide retention, and determination of erythrocyte deformability, IF decreased compared with the ventilation before treatment, statistical analysis was significantly different (P <0.05), indicating that changes in erythrocyte deformability COPD disease progression has a certain impact