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目的探讨含左氧氟沙星及卷曲霉素的化疗方案治疗耐多药肺结核患者的临床效果。方法选取100例耐多药肺结核患者作为研究对象,按照随机分配的方式,将其分为对照组50例和观察组50例。所有患者均使用吡嗪酰胺、异烟肼以及利福喷汀进行治疗,对照组患者在此基础上使用链霉素联合乙胺丁醇进行治疗,观察组患者在此基础上使用左氧氟沙星联合卷曲霉素进行治疗。结果观察组患者的痰菌阴转率、病灶吸收有效率、空洞闭合率均明显高于对照组(P<0.05),其不良反应发生率与对照组差异无统计学意义(P>0.05)。结论对耐多药肺结核患者采用含左氧氟沙星和卷曲霉素的化疗方案进行治疗,能够提高患者的肺结核痰菌阴转率和病灶吸收率,有效控制患者的病情,且具有较高的安全性。
Objective To investigate the clinical effect of chemotherapy regimen containing levofloxacin and capillase in the treatment of multidrug-resistant pulmonary tuberculosis patients. Methods A total of 100 MDR-TB patients were selected as study subjects. According to the method of random allocation, they were divided into control group (50 cases) and observation group (50 cases). All patients were treated with pyrazinamide, isoniazid, and rifapentin, and patients in the control group were treated with streptomycin and ethambutol on the basis. Patients in the observation group were treated with levofloxacin Su treatment. Results In the observation group, the sputum negative conversion rate, lesion absorption efficiency and void closure rate were significantly higher than those in the control group (P <0.05). The incidence of adverse reactions was not significantly different from that in the control group (P> 0.05). Conclusions The treatment of multidrug-resistant pulmonary tuberculosis patients with levofloxacin and capreomycin chemotherapy can improve patients with tuberculosis sputum negative conversion rate and absorption rate of the lesion, the effective control of the patient’s condition, and has high safety.