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Objective To explore the probable function of peptidyl arginine deiminase 4 (PAD4) in rheumatoid arthritis (RA) .Methods Real-time quantitative polymerase chain reaction (PCR) was used to determine the expression of PAD4 mRNA in peripheral blood mononucleated cells (PBMCs) from 60 RA patients and 40 healthy individuals.Asymmetric di-methylation of histone H3R17,symmetric di-methylation and mono-methylation of H4R3were semi-quantified by Western blotting in 12 patients with osteoarthritis (OA) ,26 patients with RA and 10
Objective To explore the probable function of peptidyl arginine deiminase 4 (PAD4) in rheumatoid arthritis (RA). Methods Real-time quantitative polymerase chain reaction (PCR) was used to determine the expression of PAD4 mRNA in peripheral blood mononucleated cells (PBMCs) from 60 RA patients and 40 healthy individuals. Asymmetric di-methylation of histone H3R17, symmetric di-methylation and mono-methylation of H4R3were semi-quantified by Western blotting in 12 patients with osteoarthritis (OA), 26 patients with RA and 10