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目的探讨HLAⅠ、Ⅱ类基因多态性与肾综合征出血热(hemorrhagic fever with renal syn- drome,HFRS)患者临床特征的相关性。方法应用PCR-SSO(polymerase chain reaction using sequence- specific oligonucleotides)基因分型技术对中国北方地区56例汉族HFRS患者HLAⅠ、Ⅱ类基因频率分布进行了检测。结果HFRS重型组HLA-B35携带率为20％,HLA-B62及HLA-DR11携带率皆为15％,与轻型组比较差异皆具有统计学意义(P<0．05)。结论HLAⅠ类基因中HLA-B35、HLA-B62及HLAⅡ类基因中HLA-DR11与中国北方地区汉族人群HFRS患者病情严重性密切相关。
Objective To investigate the relationship between HLA class Ⅰ and Ⅱ gene polymorphisms and clinical features of patients with hemorrhagic fever with renal syn-drome (HFRS). Methods The frequency distribution of HLA class I and class II genes in 56 HFRS patients from Han nationality in northern China was detected by PCR-SSO (polymerase chain reaction using sequence-specific oligonucleotides) genotyping. Results The carrying rate of HLA-B35 in HFRS severe group was 20%, and the carrying rates of HLA-B62 and HLA-DR11 were both 15%. There were significant differences between the two groups (P <0.05). Conclusion HLA-DR11 in HLA-B35, HLA-B62 and HLA class II genes is closely related to the severity of HFRS in Han population of northern China.