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目的探讨妊娠期高血压患者血浆和肽素水平变化及其临床价值。方法收集2012年8月-2015年12月在湖州市中心医院住院的妊娠期高血压孕妇63例,分成3组,其中妊娠期高血压组22例,轻度子痫前期组20例,重度子痫前期组21例。选择同期分娩的健康孕妇30例为对照组。采用ELISA法检测各组孕妇血浆中和肽素水平,并比较其相互关系。结果轻度子痫前期组及重度子痫前期组孕妇血浆中和肽素水平均高于对照组及妊娠期高血压组,差异均有统计学意义(P<0.05);重度子痫前期组高于轻度子痫前期组,差异有统计学意义(P<0.05);妊娠期高血压组高于对照组,差异有统计学意义(P<0.05)。结论妊娠期高血压孕妇血浆和肽素表达水平明显升高,且随疾病程度加重其表达水平明显升高。提示血浆和肽素水平有助于评估妊娠期高血压的严重程度。
Objective To investigate the changes of plasma copeptin levels and its clinical value in patients with hypertensive disorders during pregnancy. Methods 63 pregnant women with hypertensive disorder complicating pregnancy were collected from August 2012 to December 2015 in Huzhou Central Hospital. They were divided into three groups, of which 22 were hypertensive gestational hypertension, 20 were mild preeclampsia, 21 cases of preeclampsia group. Select the same period of delivery of healthy pregnant women 30 cases as control group. The levels of plasma copeptin in each group were detected by ELISA, and their correlations were compared. Results The levels of plasma copeptin in pregnant women with mild preeclampsia and severe preeclampsia were significantly higher than those in the control group and gestational hypertension group (P <0.05), and those in severe preeclampsia group In mild preeclampsia group, the difference was statistically significant (P <0.05); gestational hypertension group than in the control group, the difference was statistically significant (P <0.05). Conclusion The plasma levels of Copeptin in pregnant women with hypertension during pregnancy are significantly increased, and their expression levels are significantly increased with the severity of the disease. Suggesting that plasma copeptin levels help assess the severity of gestational hypertension.