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前言冠心病是中、老年的常见病、多发病。其病死率仅次于肿瘤。因此,国内外对冠心病的研究极为重视,特别对血小板与冠心病的关系,进行了多方面的研究,其中以“血栓学说”最受重视。 1975年Samuelsson研究小组发现了血小板恶A_2(促血栓素、促凝血素、血栓素、血栓烷、Thromboxane A_2、TXA_2)具有强烈的聚集血小板及收缩冠状血管的作用。它是前列腺素内过氧化物的一个不稳定的代谢物。1976年Vane等人发现了前列腺环素(Pro-stacyclin,PGI_2)有抑制血小板聚集及舒张血管的作用,其生物活性正好与血小板恶A_2相反。许多学者认为它们在体内是一对自动平衡机制。当此平衡失调,血小板恶A_2的
Preface Coronary heart disease is a common and frequently-occurring disease in the elderly and the elderly. Its mortality is second only to the tumor. Therefore, the research on coronary heart disease at home and abroad attaches great importance, especially for the relationship between platelet and coronary heart disease, has carried out a variety of research, of which the “thrombology theory” is the most valued. In 1975, Samuelsson’s team discovered that platelet thiamine A2 (thromboxane, prothrombin, thromboxane, thromboxane, Thromboxane A_2, TXA_2) has a strong effect on platelet aggregation and coronary vasoconstriction. It is an unstable metabolite of prostaglandin endoperoxide. In 1976, Vane et al. found that Pro-stacyclin (PGI 2) has the effect of inhibiting platelet aggregation and vasodilation, and its biological activity is exactly the opposite of platelet evil A2. Many scholars believe that they are a pair of automatic balance mechanisms in the body. When the balance is imbalanced, platelet evil A_2