论文部分内容阅读
目的:观察铝碳酸镁对胆汁反流性胃炎的实验大鼠和临床胆汁反流性胃炎患者的治疗效果。方法:实验研究,纵形切开大鼠胃幽门括约肌,制造胆汁反流性胃炎的实验模型并喂饲不同剂量的铝碳酸镁或硫糖铝。二周或四周后取鼠全胃分送病理光镜与电镜检查。临床研究,胃镜下诊断为胆汁反流性胃炎的患者,随机接受铝碳酸镁或硫糖铝治疗并逐日记录临床症状,疗程结束时作胃镜复查。结果:临床观察见铝碳酸镁治疗胆汁反流性胃炎的一周显效率达42.36%,总有效率为89.66%;二周的治疗显效率达70.57%,总有效率为100%;铝碳酸镁的一周疗效与硫糖铝二周疗效相似,明显优于硫糖铝对照组(P<0.01)。实验大鼠的病理光镜与电子显微镜检查结果与临床所见相同。结论:铝碳酸镁是治疗胆汁反流性胃炎的有效药物。
Objective: To observe the therapeutic effect of aluminum magnesium carbonate on experimental bile reflux gastritis rats and clinical patients with bile reflux gastritis. Methods: Experimental study, longitudinal gastric resection of the stomach pyloric sphincter, the manufacture of bile reflux gastritis experimental model and fed different doses of aluminum magnesium carbonate or sucralfate. Two weeks or four weeks after taking the whole rat gastric distribution pathological light microscopy and electron microscopy. In clinical studies, patients diagnosed with bile reflux gastritis under endoscopy were randomized to receive either aluminum magnesium carbonate or sucralfate and clinical symptoms were recorded daily, with gastroscopy at the end of the course of treatment. Results: Clinical observation showed that once a week, the effective rate of aluminum magnesium carbonate in treatment of bile reflux gastritis was 42.36%, the total effective rate was 89.66%; the effective rate of two weeks treatment was 70.57% and the total effective rate was 100% One-week efficacy and sucralfate two weeks similar efficacy, significantly better than the sucralfate control group (P <0.01). Pathological light microscopy and electron microscopy of experimental rats and clinical findings the same. Conclusion: Magnesium aluminum carbonate is an effective drug for the treatment of bile reflux gastritis.