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对100例鼻息肉的石蜡切片(其中6例兼作冰冻切片)用HE和CK13免疫组化染色,以光镜观察息肉上皮结构及CK13表达。结果发现,鼻息肉上皮有9种,其中10例达5~6种;CK13在过渡性上皮的表达不规律;4例有鳞状细胞内翻乳头状瘤样改变。提示鼻息肉上皮由于反复变性坏死而再生、增生及化生,可引起上皮的多种变化;有可能是鼻息肉和乳头状瘤共存。因而临床对鼻息肉,特别是反复发作的鼻息肉,应行病理检查,以防将内翻乳头状瘤漏诊或误诊为一般鼻息肉。
Paraffin sections of 100 cases of nasal polyps (including 6 frozen sections) were stained with HE and CK13, and the polyp epithelial structure and CK13 expression were observed with light microscope. The results showed that there are 9 kinds of nasal polyps, of which 10 cases reached 5 to 6; CK13 expression in the transitional epithelium irregular; 4 cases of squamous cell inverted papilloma-like changes. Tip nasal polyp epithelial repeatedly degeneration and necrosis and regeneration, proliferation and metaplasia, can cause a variety of epithelial changes; may be nasal polyps and papilloma coexistence. Therefore, clinical nasal polyps, especially recurrent nasal polyps, should be pathological examination, to prevent the inverted papilloma missed or misdiagnosed as general nasal polyps.