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目的掌握株洲市手足口病的主要病原学分布特征、流行规律、动态变化趋势,为预防控制手足口病提供科学依据。方法采集株洲市2010年3-12月份441例手足口病病例标本(粪便、肛拭子、咽拭子或疱疹液),通过RT-PCR方法检测人肠道病毒核酸PE、EV71和CoxA16。结果手足口病主要高发于5岁及以下儿童,尤以3岁以下儿童为主。EV71阳性率为29.25%(129/441),CoxA16阳性率为10.20%(45/441),PE阳性率为17.01%(75/441)。结论株洲市2010年手足口病病原以EV71为主,EV71感染的比例占阳性病例数的67.19%,全市所有县(市)区均有检出。
Objective To grasp the main etiological distribution, epidemic rules and trends of hand-foot-mouth disease in Zhuzhou City and provide a scientific basis for the prevention and control of hand-foot-mouth disease. Methods A total of 441 HFMD cases (stool, anal swab, throat swab or herpes fluid) were collected from March to December in 2010 in Zhuzhou City. The human enterovirus RNA (PE), EV71 and CoxA16 were detected by RT-PCR. Results HFMD mainly occurred in children aged 5 years and younger, especially children under 3 years old. The positive rate of EV71 was 29.25% (129/441), the positive rate of CoxA16 was 10.20% (45/441), and the positive rate of PE was 17.01% (75/441). Conclusion The main pathogens of HFMD in 2010 were EV71 in Zhuzhou City, accounting for 67.19% of the total number of EV71 infection in all the counties (cities) in the city.