甲状腺转录因子1(TTF-1)是一种调节基因转录的蛋白,免疫组化染色常表达于甲状腺和肺起源的肿瘤,因此日常外检工作中,经常被用于帮助确定转移癌的原发部位,尤其在鉴别肺和乳腺源性肿瘤中是非常有用的,因为两者均可呈CK7+/CK20-染色,而且有报道称与乳腺起源密切相关 Thyroid transcription factor 1 (TTF-1) is a protein that regulates gene transcription. Immunohistochemical staining is often expressed in thyroid and lung-originated tumors and is therefore routinely used to help identify the primary Site, is particularly useful in the differential diagnosis of lung and breast-derived tumors because both are CK7 + / CK20-stained and have been reported to be closely associated with the origin of the mammary gland