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目的:研究幽门螺杆菌(Hp)感染与口腔疾病的关系。方法:通过PCR方法检测口腔疾病患者和正常人牙菌斑中Hp情况。结果:牙菌斑Hp与复发性口腔溃疡(ROU)高度相关(P<0.01);与口腔扁平苔癣(OLP)、牙周炎、干槽症(DS)、龋病呈显著性相关(P<0.05);牙周炎、龋病严重程度和牙菌斑取样部位与Hp检出阳性率亦有关联(P<0.05)。结论:牙菌斑Hp感染与口腔疾病发病明显相关。“,”AIM:Investigation of the relationship between hehcobacter pylori (Hp) in dental plaque and oral diseases. METHODS: A total of 3510 subgingival dental plaque samples were collected from oral disease patients and healthy individuals, Hp was detected by PCR methods. RESULTS:The prevalance of Hp infection in recurrent oral ulcer (ROU) was highly significant(P<0.01); in oral lichen planus (OLP), periodontitis,dry socket (DS), and caries, the significant relationship (P <0.05) existed. The distribution of Hp in dental plaque had relation with activities and regions (from caries and non- caries regions,or from periodontitis and non- periodontitis regions) ( P<0.05). CONCLUSION: results showed that Hp infection in dental plaque was closey related with oral diseases.