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目的探讨枸橼酸莫沙必利片治疗胃食管反流病的疗效及安全性。方法选取2007年1月至2010年6月进行治疗的94例胃食管反流患者为研究对象,将其随机分为对照组和观察组各47例,对照组采用埃索美拉唑进行治疗,观察组在对照组的基础上加用枸橼酸莫沙必利片进行治疗,后将两组患者的治疗有效率、不良反应发生率及治疗前后的VAS评分、QOL评分及血清肿瘤坏死因子-α水平进行统计及比较。结果观察组的治疗总有效率高于对照组,不良反应发生率低于对照组,治疗后VAS评分低于对照组,QOL评分高于对照组,血清TNF-α水平低于对照组,均有显著性差异。结论枸橼酸莫沙必利片治疗胃食管反流病的疗效较好,安全性较高。
Objective To investigate the efficacy and safety of mosapride citrate tablets in the treatment of gastroesophageal reflux disease. Methods Ninety-four patients with gastroesophageal reflux disease who were treated from January 2007 to June 2010 were randomly divided into control group and observation group, with 47 cases in each group. The control group was treated with esomeprazole, The observation group was treated with mosapride citrate tablets on the basis of the control group. The treatment efficiency, incidence of adverse reactions, VAS score, QOL score and serum tumor necrosis factor - α level statistics and comparison. Results The total effective rate of observation group was higher than that of control group, and the incidence of adverse reactions was lower than that of control group. VAS score was lower than control group after treatment, QOL score was higher than that of control group, and serum TNF-α level was lower than that of control group Significant difference. Conclusion Mosapride citrate tablets are effective in treating gastroesophageal reflux disease and have higher safety.