原发性肝癌介入治疗前后肝脏血流动力学研究

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目的:应用彩色多普勒超声研究原发性肝癌(PHCC)病人介入治疗前后的血流动力学变化规律。材料和方法:选择20例PHCC病人,与20位正常人的血流动力学进行比较,20例肝癌病人介入治疗前后和介入治疗后近期和后期的血流动力学变化进行动态测定观察。测定内容包括肝固有动脉和门静脉的直径、血流速度和血流量,全肝血流量和肿瘤血流特点。结果:PHCC病人肝固有动脉内径增大、血流速度增快、血流量增多(P<0.05);虽然门静脉的血流速度减慢、门脉内径增宽、血流量也增加,但PHCC病人是以肝固有动脉血流量的骤增为特点。介入治疗后现一周内,肝固有动脉内径、血流速度和血流量均下降(P<0.05);门脉内径虽无明显变化,但血流速度和血流量均明显代偿性增加(P<0.01),致使肝脏的总血流量增加(P<0.05)。介入治疗后一个月,肝固有动脉及门静脉内径与介入治疗后一周内虽无明显变化,但两者的血流速度和血流量、以及总肝血流量均明显下降(P<0.05)。与介入治疗后近期所不同的是以肝固有动脉和门脉血流量的进一步降低、并渐恢复或接近治疗前的水平为其特点。结论:①大多数原发性肝癌病人的肝脏肿瘤是以动脉供血为主,超声测得的肝动脉血流量超过500ml/分时,对诊断PHCC有助。②介入治疗前后全肝和 Objective: To investigate the hemodynamic changes before and after interventional treatment in patients with primary liver cancer (PHCC) using color Doppler ultrasound. Materials and Methods: 20 patients with PHCC were selected and compared with the hemodynamics of 20 normal persons. The dynamic changes of hemodynamics were observed before and after interventional treatment in 20 patients with hepatocellular carcinoma. Measurements included the diameter of the proper hepatic artery and portal vein, blood flow velocity and blood flow, and hepatic blood flow and tumor blood flow characteristics. Results: The internal diameter of hepatic artery in PHCC patients increased, blood flow velocity increased, blood flow increased (P<0.05); Although the portal vein blood velocity slowed, portal diameter widened, blood flow also increased, but PHCC patients are It is characterized by a sudden increase in the blood flow of the proper hepatic arteries. Within one week after interventional therapy, the internal diameter of the hepatic artery, blood flow velocity, and blood flow decreased (P<0.05); although the diameter of the portal vein did not change significantly, the blood flow velocity and blood flow were significantly increased ( P<0.01), resulting in an increase in total blood flow in the liver (P<0.05). One month after interventional therapy, although there was no significant change in the internal diameter of the hepatic artery and portal vein within one week after interventional therapy, both the blood flow velocity, blood flow, and total hepatic blood flow were significantly decreased (P<0.05). The most recent differences after interventional treatment are characterized by a further reduction in the hepatic arterial and portal blood flow, and gradually returning to or near pre-treatment levels. Conclusion: 1 Most liver cancer patients with primary liver cancer have arterial blood supply. Ultrasound measured hepatic arterial blood flow more than 500 ml/min, which is helpful for the diagnosis of PHCC. 2 before and after treatment of whole liver and
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