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目的:探讨抗心磷脂抗体(ACA)、D-二聚体(D-Dimer)与急性脑梗死(ACI)的关系。方法:应用酶联免疫吸附试验(ELISA)对187例急性脑梗死患者清晨空腹血清中ACA、D-Dimer的含量进行检测,并与135例正常健康人群进行比较。结果:急性脑梗死组的ACA阳性率远较正常对照组高,差异显著(P<0.01);ACA阳性组D-Dimer含量显著高于ACA阴性组;脑梗死患者病情越重,血清IgG-ACA阳性率越高,D-Dimer含量也越高;随时间变化,ACA阳性率逐渐减少,第1周与第2、第3、第4周ACA相比较(P<0.01);ACA阳性与50岁(含50岁)以下脑梗死患者关系密切。结论:血清中ACA、D-Dimer动态变化对急性脑梗死的预后判断有一定帮助。
Objective: To investigate the relationship between anticardiolipin antibodies (ACA), D-dimer and acute cerebral infarction (ACI). Methods: The serum levels of ACA and D-Dimer in fasting serum of 187 patients with acute cerebral infarction were detected by enzyme linked immunosorbent assay (ELISA) and compared with 135 normal healthy subjects. Results: The positive rate of ACA in acute cerebral infarction group was significantly higher than that in normal control group (P <0.01). The content of D-Dimer in ACA positive group was significantly higher than that in negative ACA group. Serum IgG-ACA The positive rate of ACA increased gradually with the increase of positive rate. The positive rate of ACA decreased gradually with the passage of time. The positive rate of ACA in the first week was lower than ACA in the second, third and fourth week (P <0.01) (Including 50 years old) the following cerebral infarction patients are closely related. Conclusion: The dynamic changes of serum ACA and D-Dimer may be helpful to the prognosis of acute cerebral infarction.