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本实验观察了中药制剂胃肠康,对大鼠胃肠运动的影响及对胃粘膜的保护作用。实验表明:胃内注射胃肠康后,胃、十二指肠、降结肠的运动幅度增加,预先切断双侧膈下迷走神经或皮下注射阿托品,可使胃肠康增强胃肠运动的作用明显减弱;另外,该制剂可明显减低由消炎痛所致的胃粘膜损伤,预先注射阿托品、酚妥拉明、心得安等,对这一保护作用均无影响。结果提示:胃肠康可能是通过兴奋胃肠道副交感神经促进胃运动,对胃粘膜的保护作用可能与胃肠交感和副交感神经作用的关系不大。
This experiment observed the effect of traditional Chinese medicine preparation, Weichangkang, on gastrointestinal motility in rats and its protective effect on gastric mucosa. Experiments showed that: After intragastric administration of gastrointestinal tract, the range of movement of the stomach, duodenum, and descending colon increased. Preoperatively cutting off the bilateral infrapatellar vagus nerve or subcutaneous injection of atropine could significantly reduce gastrointestinal motility and enhance gastrointestinal motility. In addition, the preparation can significantly reduce the gastric mucosal damage caused by indomethacin, atropine in advance, phentolamine, propranolol, etc., have no effect on this protection. The results suggest that Weichangkang may stimulate gastric motility by exciting the parasympathetic gastrointestinal tract, and the protective effect on gastric mucosa may have little to do with gastrointestinal sympathetic and parasympathetic effects.