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目的:探讨原发性睾丸混合性生殖细胞肿瘤(MGCT)的临床病理特征。方法:对我院13例原发性睾丸MGCT患者的临床病理资料进行回顾性分析,并结合相关文献进行讨论。结果:睾丸MGCT占我院同期睾丸生殖细胞肿瘤的24.1%(13/54),患者年龄2~53岁,平均28.3岁。全部病例均发生于单侧睾丸,左侧6例,右侧7例,左右侧比为0.86∶1。睾丸MGCT病理形态多样,肿瘤成分包括胚胎性癌(11例,84.6%)、精原细胞瘤(8例,61.5%)、畸胎瘤(6例,46.2%)、绒毛膜癌及卵黄囊瘤(均为4例,23.1%)。其中9例(69.2%)包含2种不同的生殖细胞肿瘤成分,3例(30.8%)包含3种不同的肿瘤成分,1例(7.7%)包含5种不同的肿瘤成分。结论:睾丸MGCT非常少见,好发于青壮年男性,不同的肿瘤成分其生物学行为、临床治疗和预后不同,因此准确的病理诊断非常必要,免疫组化标记对病理诊断与鉴别诊断具有重要作用。
Objective: To investigate the clinical and pathological features of primary testicular germ cell tumors (MGCT). Methods: The clinical and pathological data of 13 cases of primary testicular MGCT in our hospital were retrospectively analyzed and discussed with relevant literatures. Results: Testicular MGCT accounted for 24.1% (13/54) of the testicular germ cell tumors in the same period of our hospital. The patients were from 2 to 53 years old with an average age of 28.3 years. All cases occurred in unilateral testis, left 6 cases, right 7 cases, left and right side ratio of 0.86: 1. Testicular MGCT showed multiple pathological features including tumor of embryo (11 cases, 84.6%), seminoma (8 cases, 61.5%), teratoma (6 cases, 46.2%), choriocarcinoma and yolk sac tumor (All 4 cases, 23.1%). Of these, 9 (69.2%) contained 2 different germ cell tumor components, 3 (30.8%) contained 3 different tumor components and 1 (7.7%) contained 5 different tumor components. Conclusion: Testicular MGCT is very rare and occurs in young and old males. The biological behavior, clinical treatment and prognosis of different tumor components are different, so accurate pathological diagnosis is very necessary. Immunohistochemical markers play an important role in the pathological diagnosis and differential diagnosis .