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近年来神经化学方面的研究证明,前列腺素(PG)可能在中枢神经系统信息传递中具有重要作用。应用组织化学技术也发现,脑内缓激肽(BK)样免疫活性物质的分布。一些作者提出,中枢神经系统中的PG与BK可能存在某种相互作用。近来,Kariga等人为了进一步探讨PG与BK在中枢作用中的可能关系,观察了PGE_2对BK引起的血压变化和行为反应的影响。实验发现,在慢性埋植脑室瘘管的大鼠脑室内注射0.5、1、2、5nmol BK时,动物可产生双峰升压效应,且具有明显的量效关系。与此同时,动物还产生双相的行为改变,表现为短暂兴奋后的持续镇静。反复注射BK,升压反应可快速耐受。如果在使用BK前30分钟,预先在脑室注射PG生物合成抑制剂消炎痛则可抑制BK的升压效应和行为反应。如果在大鼠脑室单纯注射PGE_2也可产生与剂量相关的升压效应以及与BK类似的行为反应。反复脑室注射PGE_2,其升压效应亦可快速耐受,此时如果再在动物脑室
In recent years, neurochemical studies have shown that prostaglandins (PG) may play an important role in the central nervous system information transmission. The use of histochemical techniques also found that distribution of bradykinin (BK) -like immunoreactive substances in the brain. Some authors suggest that there may be some interaction between PG and BK in the central nervous system. Recently, Kariga et al investigated the effect of PGE_2 on BK-induced changes in blood pressure and behavior in order to further explore the possible central role of PG and BK. Experiments found that in chronic ventricular fistula rat brain intraventricular injection of 0.5,1,2,5 nmol BK, the animals can produce double-peaked pressure effect, and has a significant dose-effect relationship. At the same time, animals also produce biphasic behavioral changes, manifested as sustained sedation after a brief period of excitement. Repeated injection of BK, the pressure response can be quickly tolerated. If indomethacin, a PG biosynthesis inhibitor, is injected into the ventricles preemptively 30 minutes prior to the use of BK, the antihypertensive and behavioral responses to BK may be suppressed. A simple injection of PGE 2 in the rat ventricle also produced dose-dependent boost effects and a similar behavioral response to BK. Repeated intracerebroventricular injection of PGE_2, the vasopressor effect can also be quickly tolerated, this time if the animal ventricle