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目的 了解肝脏局部浸润淋巴细胞是否存在AICD现象及其意义。方法 采用S P法检测 10例慢性重型乙型肝炎肝组织Fas和FasL表达。结果 10例慢性重型乙型肝炎肝内浸润淋巴细胞和肝细胞皆有不同程度的Fas和FasL的表达 ,Fas和FasL在淋巴细胞和肝细胞皆以膜浆型表达为主。结论 慢性重型乙型肝炎肝组织内细胞损伤的效靶关系十分复杂 ,肝组织浸润淋巴细胞存在激活诱导细胞死亡现象 ,浸润的淋巴细胞可能通过Fas/FasL介导的凋亡途径而下调免疫反应。
Objective To understand the existence and significance of AICD in local infiltrating lymphocytes in the liver. Methods S P method was used to detect the expression of Fas and FasL in 10 chronic hepatitis B patients with chronic severe hepatitis. Results The expression of Fas and FasL in 10 cases of chronic severe hepatitis B infiltrating lymphocytes and hepatocytes were different. Fas and FasL were predominantly expressed in the plasma membrane of lymphocytes and hepatocytes. CONCLUSION: The target-target relationship of cell injury in chronic severe hepatitis B is very complicated. The infiltration of lymphocytes in liver tissue induces cell death. The infiltrating lymphocytes may down-regulate the immune response through Fas / FasL-mediated apoptosis pathway.