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目的：观察拉西地平对糖尿病并发高血压和单纯高血压的治疗效果。方法：单纯高血压和糖尿病并发高血压各２５例，服安慰剂 ２ ｗｋ后服用拉西地平２ ｍｇ，如血压未降至正常，则渐增到４，６ ｍｇ或 ８ ｍｇ，ｐｏ， ｑｍ， ｐｃ，共 ６ ｗｋ。结果： ２组治疗 ２ｗｋ后收缩压分别下降达（３．４±０．６）ｋＰａ或（３．５±０．６）ｋＰａ，（Ｐ＜０．０１）；舒张压分别下降达（２．０±０． ３） ｋＰａ或（２． ２± ０． ４） ｋＰａ（ Ｐ＜ ０． ０５）。治疗 ４ ｗｋ及６ｗｋ，均显示收缩压进一步下降；舒张压均维持原疗效；治疗６ｗｋ期间对心率、血糖、血脂均无显著影响。结论：拉西地平治疗单纯性或糖尿病并发高血压均有较好疗效。
Objective: To observe the therapeutic effect of lacidipine on diabetic complicated with hypertension and simple hypertension. Methods: 25 cases of hypertension and diabetes mellitus complicated with hypertension were treated with lacidipine 2 mg for 2 wk after placebo, and then increased to 4, 6 mg or 8 mg, po, qm if blood pressure did not decrease to normal. pc, a total of 6 wk. Results: After 2 weeks of treatment, systolic blood pressure decreased by (3.4 ± 0.6) kPa or (± 3.5 ± 0.6) kPa, respectively (P <0.01); diastolic blood pressure decreased by 2 weeks (2) 0 ± 0. 3) kPa or (2.2 ± 0.4) kPa (P <0.05). Treatment 4 wk and 6wk, showed further reduction in systolic blood pressure; diastolic blood pressure were maintained the original effect; treatment of 6wk during heart rate, blood glucose, blood lipids had no significant effect. Conclusion: Laxidipine is effective in treating simple or diabetic high blood pressure.