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Objective To explore the efficacyof Scar Infusion Instrument on expression of Type Ⅰ Collagen and Cell Proliferation Markers in Pathological Scars.Methods 70 cases patients with pathologic scar admitted in our hospital from Augst 2016 to July 2017 were randomly divided into study group and control group.The control group was treated with scar ointment.The treatment group was treated with scar ointment combined with scar The expression of COL-Ⅰ in scar tissue was determined by enzyme-linked munosorbeat assay (ELISA).The expression of ki-67 nuclear protein was determined by immunohistochemical staining (sp).Results The efficacy of the study group was significantly better than the control group,the total efficiency of the study group was significantly higher than the control group after 6 months treatment(P＜0.05);The average COL-Ⅰ and Ki67 nuclear protein expression in the single slice of the study group was significantly lower than that of the control group at the 3th months,6th months after treatment(P＜0.001).Conclusions The scarring device is more effective in the treatment of pathological scar,and its mechanism may be related to the better inhibition of COL-Ⅰ and ki-67 nucleoprotein expression